“In a time when disinformation is being laundered through government agencies, the responsibility to protect evidence-based care falls to courageous providers and principled institutions.” As of early March 2025, 600 anti-transgender bills have been introduced nationwide, and 90 have passed. In 2024, 674 anti-trans bills were proposed and 50passed. Of the potential bills in 2025 so far, 44 seek to restrict transgender bathroom access and over 168 seek to outlaw gender-affirming care or limit insurance coverage (Fact Sheet 2025). The clinical care of transgender and gender-diverse adolescents encompasses a variety of potential medical interventions that are individualized after careful assessment and shared decision-making. This approach, often referred to as gender-affirming care, includes social, psychological, and familial support as well as medical interventions. Clinicians, partnering with families and patients, combine their expertise with an adolescents’ lived experience and work together to interpret the currently available data in light of the particular health circum-stances of the adolescent.